Editing Dr. Alphonse Mephesto (section)

==Video Games==
===[[South Park: Tenorman's Revenge]]===
Dr. Mephesto does not appear in the game, but he is mentioned by [[Scott Tenorman]], who releases many of the doctor's creations as mini-bosses. According to [http://www.ign.com/articles/2012/03/05/gingers-attack-in-south-park-tenormans-revenge early press information], it is also [[Dr. Alphonse Mephesto]] who is helping the boys repair the time stream in their battle against [[Scott Tenorman]].

===[[South Park: The Fractured But Whole]]===
The character plays a key role in the game's central storyline, where the player is tasked to visit the [[South Park Genetic Engineering Ranch]] to uncover [[Mitch Conner|the villain's]] efforts to have cats and his henchmen genetically altered. The level "The Many Asses of Dr. Mephesto", styled on a classic dungeon crawl, portrays the location radically different from the series, featuring it as a sprawling science facility with a wide, bustling variety of scientists, employed under the 'Mephesto's Tech' banner, with the interior visually resembling the Visitor's Center from the 1993 film ''Jurassic Park'', with Dr. Mephesto playing a role as a tour guide. Though he retains his penchant for multi-assed animals and bizarre hybrids, his assistant Kevin is absent and never mentioned, and his son Terrance is indicated to have died long ago, despite evidence to the contrary.

After the end of a lengthy tour of each level of the facility, including a greenhouse, animal enclosures and failed clones of his dead son, Mephesto explains that the facility is funded by donors, including [[Mitch Conner|the villain]], who has asked him to genetically alter cats and [[Sixth Graders|local sixth graders]], boosting their aggression and number of asses, for his operation. When the complex security grid is turned off, the player is forced to lead the children and Mephesto through the facility to escape, killing many of his creations in the process, while Mephesto struggles with his own technological designs, including opening electrified doors. The player eventually escapes the facility, and can return to the main hall at any time to snap a selfie with him for Coonstagram.

As Mephesto's ranch looks wildly different from the show, his assistant Kevin is not present, and Terrance has continued to appear in the background of episodes after its release, in addition several episodes after his death is suggested to have taken place, these scenes are presumably non-canon. The facility seems to return to its classic appearance by "[[South Park: Phone Destroyer]]", published by Ubisoft one month later.

===[[South Park: Phone Destroyer]]===
During the character creation process, Mephesto can be seen working in his laboratory in the background, with his sons occasionally walking past.